Cell communication and signaling : CCS
HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling.
Shishuo Sun, Wanxin Zhao, Yibing Liang, Ying Xue, Qihong Li, Yifan Yuan, Zhenyu Wang, Xiaoge Gao, Yizhou Yao, Haiheng Xu, Hailong Li, Xiaoxiao Liu, Patrick Ming-Kuen Tang, Junnian Zheng, Qing Zhang
Published: 202610.1186/s12964-025-02648-4
Abstract
BACKGROUND: Chimeric antigen receptor (CAR) T cell therapy has shown success in hematological malignancies, but its efficacy against solid tumors remains limited. Herpesvirus entry mediator (HVEM), a co-stimulatory molecule, enhances CAR T cell activ…
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