Cell communication and signaling : CCSMicroRNAsTranscription FactorsGene Regulatory NetworksHumansZinc Finger E-box-Binding Homeobox 1
Strongly regulated transcription factors exert an outsized influence in microRNA-regulated networks.
Laura Sourdin, Julie M Bracken, Philip A Gregory, Nora Feldker, Thomas Brabletz, Simone Brabletz, Yeesim Khew-Goodall, Gregory J Goodall, Katherine A Pillman, Cameron P Bracken
Published: 202510.1186/s12964-025-02626-w
Abstract
Identifying the most biologically meaningful microRNA (miRNA) targets remains challenging, as predictive and biochemical methods yield many weak or non-productive interactions. Transcription factors (TFs) are enriched among miRNA targets and amplify…
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