Journal of nanobiotechnologyAnimalsNanofibersMiceHumansLiver
Bidirectional regulation of liver sinusoidal clearance by amino acid nanofibers and IGFBP4 complex: effects on HbA1c.
Aejin Lee, Silvia de Lamo Castelli, Patrick Sellers, Sagarika Taneja, Mayreli Ortiz, Devan Kowdley, Jacob H Leung, Binod Pokharel, Latha P Ganesan, Bradley J Needleman, Sabrena F Noria, Luis Rodriguez-Saona, Lianbo Yu, Jon R Parquette, Ouliana Ziouzenkova
Published: 202510.1186/s12951-025-03943-5
Abstract
Therapies for type 2 diabetes primarily target hyperglycemia; however, complications are also triggered by advanced glycation end products (AGEs). We hypothesize that the anti-diabetic efficacy of insulin-like growth factor-binding protein 4 (IGFBP4)…
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