Molecular cancer
METTL3-mediated m6A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca2+ signaling.
Chaotao Chen, Kai Xiong, Feiyuan Liang, Yanping Zhong, Xiong Qin, Nanchang Huang, Yuqi Fang, Bo Zhu, Jianwen Cheng, Qingjun Wei, Li Zheng, Jinmin Zhao
Published: 202610.1186/s12943-025-02553-x
Abstract
BACKGROUND: Osteosarcoma (OS) is the most prevalent primary cancer of the bone. Metastasis and chemoresistance are the major obstacles to the improvement of OS prognosis, in which N6-methyladenosine (m6A) modification plays an important role, but the…
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