Cancer cell international
Circulating extracellular vesicle PTPRO methylation: an exploratory biomarker for minimally invasive diagnosis of early-stage lung adenocarcinoma.
Hongmei Dong, Shuanglong Chen, Weiheng Cui, Pingshan Yang, Fan Liu, Songwang Cai, Hongzheng Ren, Shuyao Zhang, Shegan Gao, Hao Zhang
Published: 202610.1186/s12935-025-04127-9
Abstract
Protein tyrosine phosphatase receptor-type O (PTPRO), a member of the PTP family, has garnered attention for its diagnostic and prognostic potential through the methylation of circulating tumor DNA (ctDNA). However, the utility of ctDNA has shown lim…
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