Microbial cell factories
Gold nanoparticle-mediated metabolic engineering in Trichoderma longibrachiatum MD33 unveils a hybrid terpenoid-alkaloid pathway for enhanced dendrobine biosynthesis.
Surendra Sarsaiya, Archana Jain, Jishuang Chen, Qihai Gong
Published: 202610.1186/s12934-026-02936-9
Abstract
BACKGROUND: Dendrobine, a neuroprotective and anticancer sesquiterpenic alkaloid, is primarily sourced from endangered Dendrobium orchids, posing sustainability challenges to its production. Endophytic fungi, such as Trichoderma longibrachiatum MD33,…
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