Microbial cell factories
Heterotrophic fermentation of a robust human defensin in Chlamydomonas reinhardtii provides a stable and potent antibacterial.
Jiayan Yi, Ji Zhang, Xiaoping Chen, Siyuan Liu, Yaxuan Qiu, Xiangrui Meng, Can Li, Zhangfeng Hu, Weihua Wang, Li Feng
Published: 202610.1186/s12934-025-02916-5
Abstract
BACKGROUND: The growing threat of antibiotic resistance underscores the urgent need for novel therapeutic agents. Antimicrobial peptides (AMPs), such as human defensins, are promising candidates due to their broad-spectrum activities, but their wides…
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