Respiratory research
DNMT1 deficiency promotes pulmonary vascular remodeling in pulmonary hypertension through epigenetic upregulation of BMP7.
Yong-Bing Wang, Lei Gao, Jia-Xin Wang, Zhe Mei, You-Li Fan, Xuan Gao, Jing Huang, Bin-Feng Sun, Yu-Fei Gao, Na Sun, Xiao-Dong Zheng, Bing-Xiang Wu
Published: 202510.1186/s12931-025-03436-x
Abstract
BACKGROUND: Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder marked by pathological vascular remodeling, predominantly driven by the hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Although bone morphogenetic…
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