BMC biology
Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions.
Adrian Kobiela, Mikołaj Klimczuk, Paweł Kamil Serafin, Kamila Kitowska, Anna Biernacka, Reza Abouali, Jorge Bernardino de la Serna, Xinwen Wang, Felicja Gajdowska, Aniela Kosobucka, Aleksandra Małgorzata Siedlar, Amandine Hauer, Lilit Hovhannisyan, Aleksandra Bogucka, Jos P H Smits
Published: 202610.1186/s12915-025-02499-y
Abstract
BACKGROUND: Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood. Insufficiency in the late epidermal protein filaggrin is frequen…
Preview only. Read the full abstract at the source