Quantitative analysis of time-related parameters in uroflowmetry curve patterns in patients with benign prostatic hyperplasia and bladder outlet obstruction: a single-center retrospective study.

OBJECTIVE: This study was designed to quantitatively analyze time-related parameters in uroflowmetry curve patterns in patients with benign prostatic hyperplasia and bladder outlet obstruction, and to investigate their potential clinical implications. METHODS: A total of 63 patients were included in this retrospective, single-center study. The benign prostatic hyperplasia (BPH) with benign prostatic obstruction(BPO) group consisted of 37 patients, while the nromal group included 26 individuals. Urodynamic study traces and clinical data were analyzed based on inclusion and exclusion criteria. Time-related parameters, including: Time to Qmax (T1), The time from Qmax to the end of uroflow (T2), and Uroflow time (T3 = T1 + T2), as well as corresponding ratios, were quantified and compared between the two groups. RESULTS: Significant differences were observed in several time-related parameters between the BPH with BPO group and the normal group. There following parameters demonstrated statistically significant differences: T1 [5 (3.25, 7) s vs. 8.5 (6, 11.5) s, p = 0.00], T2 [23 (15, 34.5) s vs. 10 (6.75, 13.25) s, p = 0.00], T3 [30 (20, 40.5) s vs. 19 (14.75, 23.25) s, p = 0.00], T1/T2 [0.20 (0.13, 0.30) vs. 0.89 (0.65, 1.12), p = 0.00], T1/T3 [0.18 ± 0.10 vs. 0.47 ± 0.10, p = 0.00], T2/T3 [0.82 ± 0.10 vs. 0.54 ± 0.09, p = 0.00].The BPH with BOO group exhibited a shorter time to Qmax onset but significantly prolonged overall voiding duration, a pattern that was consistent with the distinctive "comet tail-like" morphology frequently observed in their uroflowmetry curves. Furthermore, several time-related parameters were identified as potential independent risk factors for bladder outlet obstruction index (BOOI). CONCLUSION: The time-related parameters in uroflowmetry curve patterns in BPH patients with BPO show distinct characteristics compared to the normal group. These findings suggest that such parameters may serve as valuable diagnostic indicators for bladder outlet obstruction, though further studies with larger sample sizes are needed for confirmation.