Correlation between 25-hydroxyvitamin D, N-terminal pro-brain natriuretic peptide, inflammatory factors and myocardial injury in children with mycoplasma pneumoniae pneumonia.

OBJECTIVE: The purpose of this study was to examine the relationship between myocardial injury in children with Mycoplasma pneumoniae pneumonia (MPP) and changes in serum 25-hydroxyvitamin D (25-(OH)-D), N-terminal pro-brain natriuretic peptide (NT-proBNP), and related inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP). METHODS: The study included 300 children with MPP who were hospitalized to Zhangye People's Hospital, affiliated with Hexi College, between January 2023 and December 2023. Children with myocardial injury were assigned to Group A, while those without were assigned to Group B. The two groups' levels of NT-proBNP, 25-(OH)-D, and associated inflammatory markers were measured and compared. RESULTS: Pearson correlation analysis confirmed the association between myocardial damage and alterations in 25-(OH)-D, NT-proBNP, and associated inflammatory markers in children with MPP. Group A children had lower 25-(OH)-D levels than Group B children (p < 0.05), while Group B children had significantly greater levels of NT-proBNP, TNF-α, IL-1β, IL-6, and hs-CRP (p < 0.05). The results of Pearson correlation analysis revealed that the occurrence of myocardial injury in MPP patients could be associated with the levels of 25-(OH)-D, NT-proBNP, TNF-α, IL-1β, IL-6, and hs-CRP. CONCLUSION: It can be concluded that MPP patients may experience myocardial injury when 25-(OH)-D levels decrease and NT-proBNP and related inflammatory factors increase. Therefore, changes in the levels of these indicators should be taken into account when carrying out clinical treatment.