BMC cancer
Integrative multi-omics reveal a CD4⁺ T cell-derived six-gene signature linking the immune-stromal ecosystem to prognosis and immunotherapy selection in pancreatic cancer.
Yuxin Liang, Shuoshuo Ma, Xing Chen, Yuhao Su, Deyuan Zhong, Hongtao Yan, Yahui Chen, Ming Wang, Zhengwei Leng, Xiaolun Huang
Published: 202610.1186/s12885-026-15613-2
Abstract
BACKGROUND: Pancreatic cancer (PC) exhibits dismal outcomes and an immune-excluded microenvironment that blunts immunotherapy. Robust, immune-anchored biomarkers are needed to stratify risk and inform treatment design. METHODS: We integrated The Canc…
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