T-cell exhaustion indicator characterizes the tumor microenvironment landscape and predicts colon adenocarcinoma prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing.

BACKGROUND: Colon adenocarcinoma (COAD) is the most common type of colon cancer, posing a significant threat to public health. In the tumor microenvironment (TME), T cells differentiate into terminally exhausted T cells (TEX), but the relationship be…

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