Effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm.

BACKGROUND: Cerebral vasospasm and delayed cerebral ischemia were significant complications in patients undergoing Clipping Intracranial Aneurysm surgery. The impact of intraoperative hypercapnia on postoperative brain function and cognitive outcomes in this patient population was an area of increasing interest. This study aimed to investigate the effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm. METHODS: Adult patients who underwent Clipping Intracranial Aneurysm surgery were included in this retrospective cohort study and were divided into the No Hypercapnia group (PaCO2 = 35-45 mmHg, n = 65) and the Hypercapnia group (PaCO2>45 mmHg, n = 68) based on the occurrence of intraoperative hypercapnia. Various parameters including baseline characteristics, intraoperative parameters, anesthetic doses, postoperative brain functional network connectivity, and cognitive function were compared between the two groups. RESULTS: Baseline characteristics revealed no significant differences between the two groups. Anesthetic doses did not differ significantly between the groups. Postoperative brain functional network connectivity showed significant differences between the groups, with lower connectivity in the Hypercapnia group. Postoperative Mini-Mental State Examination scores were significantly higher in the Hypercapnia group. CONCLUSION: The study provides novel insights into the effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm surgery. TRIAL REGISTRATION: Not applicable.