Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.

OBJECTIVE: The triglyceride-glucose (TyG) index and its related parameters are biomarkers of insulin resistance (IR) and maybe of great significance for predicting the occurrence of stroke. This systematic review and meta-analysis aimed to summarize the relationship between TyG and its related parameters with the risks of stroke. METHODS: By searching the Cochrane Library, Embase, and PubMed databases, we obtained prospective cohort studies that reported the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the association between the TyG index and its related parameters (TyG-BMI, TyG-WC, TyG-WHtR) and stroke incidence. The results were combined using a random-effects model. RESULTS: This meta-analysis included 21 prospective cohort studies with a total of 6,511,326 participants. The results showed that, compared to the lowest group for TyG or its related parameters, the highest group had an increased risk of stroke (TyG-BMI: HR: 1.55, 95% CI: 1.22-1.99, I2 = 84.69%; TyG-WC: HR: 1.63, 95% CI:1.17-2.28, I2 = 89.51%; TyG-WHtR: HR: 1.79, 95%CI:1.17-2.72, I2 = 93.91%). Subgroup analyses revealed that the relationship between TyG and its related parameters and stroke was not significantly affected by gender, region, sample size, and follow-up duration. CONCLUSIONS: Higher levels of TyG, TyG-BMI, TyG-WC, and TyG-WHtR may indicate a higher risk of stroke occurrence.