A study on the correlation between novel metabolic and inflammatory-derived indicators (TyG, THR, NHR, UHR) and overweight older adult patients with T2DM.

OBJECTIVE: To evaluate the correlation between novel metabolic and inflammatory-derived Indicators (TyG, THR, NHR, UHR) for overweight in older adult type 2 diabetes mellitus (T2DM) patients. METHODS: This study enrolled 183 hospitalized older adult T2DM patients (aged ≥ 60 years) from 2023 to 2024. Participants were stratified into overweight (24 ≤ BMI < 28, n = 85) and normal-weight groups (18.5 ≤ BMI < 24, n = 98). Clinical parameters including TyG, THR, NHR, and UHR were calculated. Statistical analyses involved t-tests, logistic regression, Spearman correlation, and ROC curves. RESULTS: Key metabolic/inflammatory derived indices (TyG, THR, NHR, UHR) were significantly elevated in overweight group versus normal group (all P < 0.05). BMI showed positive correlations with TyG, THR, NHR, and UHR (all P < 0.05). Logistic regression confirmed the TyG, THR, NHR and UHR index are significantly associated with the development of overweight in T2DM patients (all P < 0.05). After adjusting for confounders, TyG demonstrated the highest predictive accuracy for overweight status (AUC = 0.732), followed by THR, NHR and UHR. CONCLUSION: TyG, THR, NHR and UHR are significantly associated with overweight in older adult T2DM, potentially serving as simple screening tools for early metabolic risk stratification and weight management.