Exploring the impact of pan-immune-inflammation-value and other traditional inflammation-based markers on coronary collateral circulation in patients with chronic total occlusion.

BACKGROUND: Coronary collateral circulation (CCC) plays a pivotal role in mitigating the adverse effects of chronic total occlusion (CTO) by providing an alternative blood supply to ischemic myocardium. In recent years, there has been a growing interest in understanding the relationship between inflammation and coronary collateral development. However, the predictive role of pan immune inflammation value (PIV), a new and expanded inflammatory response marker, on CCC has not yet been investigated. This article aims to provide a detailed comparison of the effect of PIV and other traditional inflammation-based markers on CCC in patients with CTO. METHODS: 467 patients who underwent coronary angiography due to non-ST elevation myocardial infarction (NSTEMI) and were detected to have CTO in epicardial coronary artery were included in the study. The patients were divided into two groups as poor CCC and good CCC according to the Rentrop classification, and the inflammation-based marker values of the groups were compared. RESULTS: The PIV values of NSTEMI patients were significantly higher in the poor CCC group than those in the good CCC group. High PIV values were determined as independent predictors for poor CCC (OR: 0.832, CI: 0.791-0.876, p < 0.001). With a 79% sensitivity and 78% specificity at the optimal cut-off value of 628.8, PIV demonstrated good predictive ability for identifying poor CCC (AUC: 0.785, CI: 0.744-0.826, p < 0.001). CONCLUSION: PIV was found to be superior to traditional inflammation-based markers in discriminating pooc CCC in NSTEMI patients.