Cellular & molecular biology letters
The cancer-testis lncRNA LINC01940 promotes gastric cancer malignant progression and chemoresistance by enhancing ribosome biogenesis via TAF15-mediated NOL11 SUMOylation.
Weijie Zang, Debiao Fan, Zhuang Lu, Xian Gao, Danjie Xing, Guangze Zhang, Lei Liu, Jianfeng Yi, Junjie Chen, Yilin Hu, Wanjiang Xue
Published: 202510.1186/s11658-025-00840-5
Abstract
BACKGROUND: Aberrant ribosome biogenesis promotes gastric cancer (GC) progression and contributes to chemoresistance by sustaining protein synthesis, upon which GC cell survival depends. However, the regulatory role of cancer-testis-associated long n…
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