The European respiratory journal
The transcriptome of CD14+CD163-HLA-DRlow monocytes predicts mortality in Idiopathic Pulmonary Fibrosis.
Theodoros Karampitsakos, Minxue Jia, Bochra Tourki, Zainab Fatima, Bogdan Visinescu, Carole Y Perrot, Tamer Fadli, Amy Zhao, Avraham Unterman, Marc A Schneider, Debabrata Bandyopadhyay, Brenda M Juan-Guardela, Ioannis Vamvakaris, Antje Prasse, Imre Noth
Published: 202510.1183/13993003.00804-2025
Abstract
BACKGROUND: The association between immune-cell-specific transcriptomic profiles and mortality in IPF is unknown. METHODS: We profiled peripheral blood mononuclear cells (PBMC) by single-cell RNA sequencing (scRNA-seq) and investigated which immune-c…
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