Blood advances
FLT3-directed BiTE Molecules versus CAR T Cells in AML: Co-stimulatory Signals Mitigate T-Cell Exhaustion.
Lisa Rohrbacher, Daniel Nixdorf, Helena Stadler, Bettina Brauchle, Florian Märkl, Adrian Gottschlich, Gordon Victor Hoffmann, Nora Philipp, Gerulf Hänel, Martin Edwin Kirmaier, Anetta Marcinek, Maryam Kazerani, Daniel Richter, Giulia Magno, Rebecca L Goldstein
Published: 202510.1182/bloodadvances.2025018168
Abstract
T-cell-based immunotherapies have revolutionized treatment paradigms in B-cell malignancies, yet their translation to acute myeloid leukemia (AML) has been hindered by a scarcity of tumor-restricted antigens and the risk of on-target off-leukemia tox…
Preview only. Read the full abstract at the source