Blood advances
Spectrum, prevalence, and clinical correlates of PPM1D mutations in patients with clonal hematopoiesis and clonal cytopenias.
Talha Badar, Ludovica Marando, Eric Latorre-Crespo, Terra L Lasho, Francyess Denis Oliva, Chenyu Lin, Benjamin J McCormick, Mobachir El Kettani, Kashish Shah, Yael N Kusne, Omer Jamy, Kendall Diebold, Alexander Coltoff, Christy M Finke, James M Foran
Published: 202610.1182/bloodadvances.2025018031
Abstract
TP53 and PPM1D are key regulators of DNA damage response and repair and somatic mutations in these genes often co-occur in hematopoietic cells, expanding under genotoxic stress. Unlike with TP53 mutations, where mechanisms of progression are defined,…
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