Blood advances
Towards New Therapy Endpoints in Polycythemia Vera: Targeting Clonal and Inflammatory Pathways.
Tiziano Barbui, Joseph Michael Scandura
Published: 202510.1182/bloodadvances.2025018011
Abstract
Although phlebotomy and hydroxyurea (HU) are standard first-line therapies for polycythaemia vera (PV), they do not adequately address clonal expansion and chronic inflammation - key drivers of thrombosis, myelofibrosis and mortality. Biomarkers such…
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