Blood advances
Role of Rubicon in Platelets: A Promoter of Thrombosis but Not an Autophagy Repressor.
Hammodah R Alfar, Elizabeth R Driehaus, Alexis N Smith, Daniëlle Marije Coenen, Dlovan F D Mahmood, Jeremy P Wood, Sidney W Whiteheart
Published: 202510.1182/bloodadvances.2025017486
Abstract
Rubicon (RUN domain Beclin-1-interacting and cysteine-rich-containing protein) is a negative regulator of autophagy in nucleated cells; however, its role in platelets is unstudied. Here, we identify an autophagy-independent role for Rubicon in arteri…
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