In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells.

In response to anemia, the erythroid lineage significantly expands. This growth is driven by extramedullary erythropoiesis in mice, but is additionally regulated within the bone marrow (BM) of rats, a process likely conserved in humans due to similar…

Preview only. Read the full abstract at the source