Blood advances
Lipid Metabolism Transcriptomic Signature of Defective Erythropoiesis in Diamond Blackfan Anemia syndrome.
Kaiwen Deng, Yu Wang, Joseph C Min, Xiaofeng Liu, Hiroki Ueharu, Greggory Myers, Lei Yu, Susan B Hammoud, Adham Adam, Rilie Saba, Vaneesha Natogi, Claire Drysdale, Brandon Chen, Jennifer Lai Yee, Jacob Kitzman
Published: 202610.1182/bloodadvances.2025017318
Abstract
Analysis of Diamond Blackfan anemia syndrome (DBAS) cohorts and animal models have not revealed a potential mechanism for the variable anemia phenotype, a key feature of this disease. Here, we utilized an established Rpl5Skax23-Jus/+ murine DBAS mode…
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