Blood advances
Vulnerability of SRSF2 mutated chronic myelomonocytic leukemia to perturbation of cGAS-STING pathway.
Yanan Chen, Koon Chuen Chan, Chun Fung Sin, Lichuan Zheng, Dandan Wang, Lingge Tu, Fangfang He, Wan Hei Jeffrey Hui, Hoi Ki Leung, Leslie Kar Fai Chan, Sze Pui Tsui, Hoi-Yi Chan, Alvin Chun Hang Ma, Anskar Yh Leung, Xuan Sun
Published: 202510.1182/bloodadvances.2025017005
Abstract
Chronic myelomonocytic leukemia (CMML) is characterised by monocytosis in blood and bone marrow and natural progression to acute myeloid leukemia (AML) in up to 30% of patients. The mutation landscape of CMML has been reported, and animal models that…
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