Blood advances
The Na/K-ATPase Alpha-1 Subunit Fine-Tunes Platelet P2Y12 Function and Mediates Sex-Dimorphism-Associated Thrombosis.
Oliver Q Li, Hong Yue, Autumn DeHart, Renat Roytenberg, Angela Li, Fang Bai, Hongyu Su, Rodrigo Aguilar, Olalekan Olanipekun, Jiang Liu, Olga Fedorova, David Kennedy, Ellen Thompson, Jordan A Shavit, Sandrine V Pierre
Published: 202510.1182/bloodadvances.2025016605
Abstract
Sex differences are well-recognized in thrombotic diseases, but the underlying mechanisms remain unclear. The sodium/potassium ATPase (NKA), composed of α and β subunits, regulates ion homeostasis and plays a key role in cardiovascular function. We i…
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