Blood advancesHumansHemeFerroptosisMalariaVivax
Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria.
Milena Tavares Gomes, Isabel M Medeiros-de-Moraes, Adriana Vieira-de-Abreu, Isaclaudia G de Azevedo-Quintanilha, Thayane M Fontes, Alan de Brito Carneiro, Pedro Azambuja, Neal D Tolley, Jesse W Rowley, Barbara Albuquerque Carpinter, Marcelo U Ferreira, Raquel Muller Gonçalves, Vinicius Novaes Rocha, Ana Lúcia Rosa Nascimento, Wanessa Araújo Carvalho
Published: 202610.1182/bloodadvances.2024015623
Abstract
ABSTRACT: Malaria is a highly prevalent infectious disease caused by Plasmodium parasites. Plasmodium intraerythrocytic replication leads to hemolysis-driven intermittent febrile crises in patients. In addition, the lysis of unparasitized red blood c…
Preview only. Read the full abstract at the source