A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex.

ABSTRACT: Thrombin is generated from prothrombin through cleavage at 2 sites by the enzyme prothrombinase, composed of factor Xa (fXa) and fVa. The affinity of fXa for fVa is low, with assembly and function dependent on phospholipid (PL) membranes. S…

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