Blood
Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models.
Kodandaram Pillarisetti, Danlin Yang, Leopoldo Luistro, Jianhong Yao, Melissa Smith, Peter Vulfson, James Testa, Randolph Ponticiello, Scott R Brodeur, Bradley Heidrich, Kathryn Packman, Sanjaya Singh, Ricardo M Attar, Yusri A Elsayed, Ulrike Philippar
Published: 202510.1182/blood.2025030027
Abstract
In multiple myeloma (MM), cell-specific antigens are valuable targets for developing effective T-cell-engaging therapeutics which could provide good immune responses. Achieving a sustained immune response in recurrent MM, however, remains challenging…
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