Blood
Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan.
Francesca Ferraresso, Chad W Skaer, Zimu Wei, Manoj Paul, Woosuk Steve Hur, Hongyin Yu, Monica Seadler, Taylor H Y Chen, Wen Dai, Catherine Lapointe, Laura M Ketelboeter, Hayley Lund, Geoffrey G Rodriguez, Lih Jiin Juang, Amy W Strilchuk
Published: 202610.1182/blood.2025029834
Abstract
Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesity, and age-associated diseases such as diabetes, cancer, and Alzheimer's diseas…
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