BloodAnimalsHematopoietic Stem CellsMiceJagged-2 ProteinReceptors
A Notch trans-activation to cis-inhibition switch underlies hematopoietic stem cell aging.
Francesca Matteini, Roshana Thambyrajah, Sara Montserrat-Vazquez, Sascha Jung, Alba Ferrer-Perez, Patricia Herrero Molinero, Dina El Jaramany, Javier Lozano-Bartolomé, Eva Mejia-Ramirez, Jessica Gonzalez, Antonio Del Sol, Anna Bigas, Maria Carolina Florian
Published: 202610.1182/blood.2024026505
Abstract
ABSTRACT: Aged hematopoietic stem cells (HSCs) expand in clusters over time, while reducing their regenerative capacity and their ability to preserve the homeostasis of the hematopoietic system. The expression of Notch ligands in the bone marrow (BM)…
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