Journal of Huntington's diseaseAnimalsHumansHuntington DiseaseHuntingtin ProteinMice
Localization of mutant huntingtin with HTT Exon1 P90 C-terminal neoepitope antibodies in relation to regional and neuronal vulnerability in forebrain in Q175 mice and human huntington's disease.
Yunping Deng, Marion Joni, Hongbing Wang, Rachel Cox, Ellen Sapp, Marian DiFiglia, Anton Reiner
Published: 202610.1177/18796397251404999
Abstract
BackgroundRecent evidence suggests that accumulation of mutant exon 1 protein (HTT1a) may be critical to HD pathogenesis, but the relation of this to differential regional and cellular vulnerability in HD is unknown.ObjectiveWe assessed the contribut…
Preview only. Read the full abstract at the source