Antioxidants & redox signaling
Zinc Protoporphyrin Functions as a Ferroptosis Inducer to Activate Heme-BACH Axis and Potently Suppress IDH1-Mutant Gliomas.
Ying Yang, Yating Nie, Ruolin Wu, Ruili Han, Yuanlin Zhao, Risheng Yang, Yuan Yuan, Xing Gao, Huangtao Chen, Feng Zhang, Liying Zhang, Lijun Zhang, Xiangmei Cao, Yingmei Wang, Peizhen Hu
Published: 202510.1177/15230864251394709
Abstract
Aims: Ferroptosis shows promise as a cancer treatment due to lipid hydroperoxide accumulation in an iron-dependent manner. Isocitrate dehydrogenase 1 (IDH1) mutation is common in gliomas and D-2-hydroxyglutarate (D-2HG) sensitizes cancer cells to fer…
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