International journal of toxicology
Two-Year Inhalation Studies in Mice and Rats With HFO-1234ze(E), a Near Zero Global Warming Potential Propellant for Use in Pressurized Metered Dose Inhalers.
Paul Giffen, Matthew Jacobsen, James Cartwright, Rhiannon Hall, Natalie Waterhouse, Paul Carter, Jim Saul, Lindsay Wright, Per Aberg, Stefan Platz
Published: 202510.1177/10915818251384607
Abstract
HFO-1234ze(E) is being developed as a next-generation propellant (excipient), with near zero global warming potential, for use in pressurized metered dose inhalers. In accordance with regulatory guidance, an assessment of the carcinogenic potential o…
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