[225Ac]Ac-Macropa-PEG4-HEA125 for Targeted α Therapy in Epithelial Cell Adhesion Molecule-Positive Tumors: Conjugation, Radiolabeling, and Efficacy.

Introduction: Epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide range of epithelial malignancies, and thus is a potential target for antibody-based radiotherapy. This work describes the synthesis, labeling, and biological evaluatio…

Preview only. Read the full abstract at the source