Statistical methods in medical research
A two-stage joint modeling approach for multiple longitudinal markers and time-to-event data.
Taban Baghfalaki, Reza Hashemi, Catherine Helmer, Helene Jacqmin-Gadda
Published: 202610.1177/09622802251406588
Abstract
Joint modeling of multiple longitudinal markers and time-to-event outcomes is common in clinical studies. However, as the number of markers increases, estimation becomes computationally challenging or infeasible due to long runtimes and convergence d…
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