Cephalalgia : an international journal of headacheHumansCalcitonin Gene-Related PeptideMigraine DisordersInduced Pluripotent Stem CellsEndothelial Cells
Indirect crosstalk between signalling pathways activated by CGRP and Piezo1 in human iPSC-derived endothelial cells relevant to migraine.
Vasiliki Gkouzioti, Ali Abdollahzadeh, Francijna van den Hil, Valeria Orlova, Rashid Giniatullin, Arn M J M van den Maagdenberg, Jean-Philippe Frimat
Published: 202510.1177/03331024251404478
Abstract
BackgroundIt is becoming increasingly evident that the vasculature is implicated in migraine pathophysiology. Calcitonin gene-related peptide (CGRP) acts as one of the key migraine mediators through various mechanisms that includes endothelium-mediat…
Preview only. Read the full abstract at the source