Veterinary pathology
Pathology associated with human CAR T cell administration in NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice: A retrospective analysis.
Renata M Mammone, Elinor Willis, Pedro Ruivo, Giovanni E Finesso, Arin Cox, Charles-Antoine Assenmacher, Enrico Radaelli, Alessandra Piersigilli, Ileana C Miranda
Published: 202610.1177/03009858251409216
Abstract
Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for neoplasia and autoimmune diseases. Immunocompromised mice are a common model to test the efficacy and safety of CAR T cells of human origin. Preclinical toxicity associated w…
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