Journal of psychopharmacology (Oxford, England)AnimalsHumansCitalopramCytochrome P-450 CYP3AMajor Depressive Disorder
Differential metabolism of citalopram by 21 CYP3A4 variants: An in vitro experiment.
Peng Wang, Xiaoxia Hu, Junwei Li
Published: 202510.1177/02698811251375888
Abstract
BACKGROUND: Citalopram is widely used for treating major depressive disorder, but exhibits substantial inter-individual variation in clinical response. CYP3A4 is one of the cytochrome P450 enzymes (CYP450) involved in the demethylation metabolism of…
Preview only. Read the full abstract at the source