Alternatives to laboratory animals : ATLASkin Irritancy TestsHumansInsect RepellentsAnimal Testing AlternativesInsecticides
The impossible made possible through the use of New Approach Methodologies: Dermal safety assessment of potential insect repellent or insecticidal active ingredients using a high-throughput approach to the in vitro Skin Irritation Test (OECD TG 439).
Huang Huang, Jacob N Sanders, Gregory L Warren, Andrew Patron, Anna Ninobla, Kei Inoue, Henry Valk, Michael Sadler, Benjamin Amorelli, Megan Hanson, Emily Acquaviva, Emma Lear, Megan Creelman, Courtney Nabua, Ethan Pilat
Published: 202610.1177/02611929251408412
Abstract
Toxicological profiling is a critical component of the regulatory process required to inform the hazard characterisation and labelling of chemicals, thus guiding their safe handling and use. Skin irritation is a key endpoint for regulatory registrati…
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