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Multimodal Analyses of Early, Untreated SSc Skin Identify a Proinflammatory Vascular Niche of Macrophage-Fibroblast Signaling.
Helen C Jarnagin, Rezvan Parvizi, Zhiyun Gong, Rosemary Gedert, Xianying Xing, Lam Alex C Tsoi, Rachael Bogle, Madeline J Morrisson, Laurent Perreard, Patricia A Pioli, Fred Kolling Iv, Johann E Gudjonsson, Dinesh Khanna, Michael L Whitfield
Published: 202510.1172/jci.insight.198954
Abstract
Uncovering the early interactions and spatial distribution of dermal fibroblasts and immune cells in treatment-naïve diffuse cutaneous systemic sclerosis (dcSSc) patients is critical to understanding the earliest events of skin fibrosis. We generated…
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