JCI insightAnimalsMacaca mulattaSimian Immunodeficiency VirusSimian Acquired Immunodeficiency SyndromeReceptors
RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa.
Chrysostomos Perdios, Naveen Suresh Babu, Celeste D Coleman, Anna T Brown, Shevon N Alexander, Matilda J Moström, Carolina Allers, Lara Doyle-Meyers, Christine M Fennessey, Lori A Rowe, Brandon F Keele, Amitinder Kaur, Michael L Freeman, Joseph C Mudd
Published: 202610.1172/jci.insight.198743
Abstract
Cytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with HIV-1 persistence and particular inflammatory-related comorbidities. The true causative rol…
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