JCI insightHumansMelanomaImmune Checkpoint InhibitorsCTLA-4 AntigenProgrammed Cell Death 1 Receptor
Pretreatment naive T cells are associated with severe irAE following PD-1/CTLA-4 checkpoint blockade for melanoma.
Kathryne E Marks, Alice Horisberger, Mehreen Elahee, Ifeoluwakiisi A Adejoorin, Nilasha Ghosh, Michael Postow, Laura Donlin, Anne R Bass, Deepak A Rao
Published: 202610.1172/jci.insight.198203
Abstract
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-CTLA-4 antibodies are used to induce an immune response against many types of tumors. However, ICIs often also induce autoimmune responses, referred to as immune-related adverse events (i…
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