JCI insightHumansArthritisJuvenileSynovial MembraneTranscriptome
Spatial transcriptomics reveals immune-stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis.
Jun Inamo, Roselyn Fierkens, Michael R Clay, Anna Helena Jonsson, Clara Lin, Kari Hayes, Nathan Rogers, Heather Leach, Kentaro Yomogida
Published: 202610.1172/jci.insight.198074
Abstract
Juvenile idiopathic arthritis (JIA) is the most prevalent chronic inflammatory arthritis of childhood, yet the spatial organization in the synovium remains poorly understood. Here, we perform subcellular-resolution spatial transcriptomic profiling of…
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