JCI insightHumansAutoantibodiesRheumatic FeverChildAutoantigens
PhIP-Seq uncovers marked heterogeneity in acute rheumatic fever autoantibodies.
Reuben McGregor, Lauren H Carlton, Timothy J O'Donnell, Elliot Merritt, Campbell R Sheen, Florina Chan Mow, William John Martin, Michael G Baker, Nigel Wilson, Uri Laserson, Nicole J Moreland
Published: 202610.1172/jci.insight.196619
Abstract
Acute rheumatic fever (ARF) and associated rheumatic heart disease are serious sequelae after infection with group A Streptococcus (Strep A). Autoantibodies are thought to contribute to pathogenesis, with deeper exploration of the autoantibody repert…
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