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Loss of TRPV4 reduces pancreatic cancer growth and metastasis.
Joelle M-J Romac, Sandip M Swain, Nidula Mullappilly, Bandana Bindhani, Rodger A Liddle
Published: 202510.1172/jci.insight.196280
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a rapidly metastasizing cancer characterized by a dense desmoplastic stroma composed of extracellular matrix (ECM) proteins, which complicates treatment. Upon stimulation, pancreatic stellate cells (PSCs) di…
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