JCI insightGlioblastomaAnimalsMiceHumansLipid Metabolism
Enhanced lipid metabolism serves as a metabolic vulnerability to polyunsaturated fatty acids in glioblastoma.
Shiva Kant, Yi Zhao, Pravin Kesarwani, Kumari Alka, Jacob F Oyeniyi, Ghulam Mohammad, Nadia Ashrafi, Stewart F Graham, C Ryan Miller, Prakash Chinnaiyan
Published: 202610.1172/jci.insight.191465
Abstract
Enhanced lipid metabolism, which involves the active import, storage, and utilization of fatty acids from the tumor microenvironment, plays a contributory role in malignant glioma transformation, thereby serving as an important gain of function. In t…
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