JCI insightAnimalsReceptorsN-Methyl-D-AspartateMiceDisks Large Homolog 4 Protein
Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling.
Robert E Featherstone, Hongbin Li, Ameet S Sengar, Karin E Borgmann-Winter, Olya Melnychenko, Lindsey M Crown, Ray L Gifford, Felix Amirfathi, Anamika Banerjee, AiVi Tran, Krishna Parekh, Margaret Heller, Wenyu Zhang, Robert J Gallop, Adam D Marc
Published: 202610.1172/jci.insight.189634
Abstract
The complex and heterogeneous genetic architecture of neuropsychiatric illnesses compels us to look beyond individual risk genes for therapeutic strategies and target the interactive dynamics and convergence of their protein products. A mechanistic s…
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