JCI insightAnimalsOsteoblastsAngiopoietin-like ProteinsMiceMesenchymal Stem Cells
Angiopoietin-like 8 governs osteoblast-adipocyte lineage commitment during skeletal aging.
Yaming Guo, Zeqing Zhang, Junyu He, Peiqiong Luo, Zhihan Wang, Yurong Zhu, Xiaoyu Meng, Limeng Pan, Ranran Kan, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Yan Yang, Fengjing Guo
Published: 202510.1172/jci.insight.189371
Abstract
A distinguishing feature of older mesenchymal stem cells (MSCs) from bone marrow (BM) is the transition in their differentiation capabilities from osteoblasts to adipocytes. However, the mechanisms underlying these cellular events during the aging pr…
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